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がんの早期診断に有効なマーカーの検索、また化学療法や免疫療法、放射線療法などに抵抗性のがんも含めた新たな治療法の開発を行います。いずれも高度な基礎研究から臨床応用へと発展させることにより府民の健康と、ひいては我が国、世界のがん患者への貢献を目指します。

臨床研究
管理センター

当センターの基本方針のひとつである「先進医療の開発と実践」を実現するために、企業主導および医師主導の開発治験を推進し、当センター独自の臨床研究の支援を行っています。また2018年からは、認定臨床研究審査委員会を置き、センター内外の特定臨床研究の審査も実施しています。

次世代がん医療
開発センター

患者さんの生体試料などの収集や提供(Cancer Cell Portがんバンク)、治験や臨床研究にかかる支援や外部との共同研究の誘致などの支援活動を通じて、病院や研究所との架け橋となり、基礎研究や臨床研究の推進・普及のために活動しています。

がん対策センター

1962年から継続している大阪府がん登録を基盤に、大阪府がん対策推進計画など、科学的根拠に基づくがん対策の立案および進捗管理で大阪府と協働することに加え、病院や研究所等とともに大阪国際がんセンターを構成する柱の一つとして、その理念の実践に取り組んでいます。

Research Achievement

In English

2018

  • Drozdov D, Bonaventure A, Nakata K, Suttorp M, Belot A. Temporal trends in the proportion of “cure” in children, adolescents, and young adults diagnosed with chronic myeloid leukemia in England: A population-based study. Pediatr Blood Cancer. 2018;65(12): e27422.
  • Miyazaki Y, Tabuchi T. Educational gradients in the use of electronic cigarettes and heat-not-burn tobacco products in Japan. PloS one.2018;13(1): e0191008.
  • Katai H, Ishikawa T, Akazawa K, Isobe Y, Miyashiro I, Oda I, Tsujitani S, Ono H, Tanabe S, Fukagawa T, Nunobe S, Kakeji Y, Nashimoto A. Registration Committee of the Japanese Gastric Cancer. Five-year survival analysis of surgically resected gastric cancer cases in Japan: a retrospective analysis of more than 100,000 patients from the nationwide registry of the Japanese Gastric Cancer Association (2001-2007). Gastric Cancer. 2018;21(1):144-154.
  • Nakata K, Ito Y, Magadi W, Bonaventure A, Stiller CA, Katanoda K, Matsuda T, Miyashiro I, Pritchard-Jones K, Rachet B. Childhood cancer incidence and survival in Japan and England: A population-based study (1993-2010). Cancer Sci. 2018;109(2):422-434.
  • Toyoda Y, Tabuchi T, Nakata K, Morishima T, Nakayama T, Miyashiro I, Hojo S, Yoshioka S. Increase in incidental detection of thyroid cancer in Osaka, Japan. Cancer Sci. 2018;109(7):2310–2314.

2017

  • Matsuda T, Nunobe S, Kosuga T, Kawahira H, Inaki N, Kitashiro S, Abe N, Miyashiro I, Nagao S, Nishizaki M, Nhiki N, Society for the Study of Laparoscopy and Endoscopy Cooperative Surgery. Laparoscopic and luminal endoscopic cooperative surgery can be a standard treatment for submucosal tumors of the stomach: a retrospective multicenter study. Endoscopy. 2017;49(5):476-483
  • Tabuchi T, Kondo N. Educational inequalities in smoking among Japanese adults aged 25-94 years: nationally representative sex- and age-specific statistics. J Epidemiol. 2017;27(4):186-192.
  • Tabuchi T, Goto A, Ito Y, Fukui K, Miyashiro I, Shinozaki T. Smoking at the time of diagnosis and mortality in cancer patients: What benefit does the quitter gain? Int J Cancer. 2017;140(8):1789-1795.
  • Katanoda K, Shibata A, Matsuda T, Hori M, Nakata K, Narita Y, Ogawa C, Munakata W, Kawai A Nishimoto H. Childhood, adolescent and young adult cancer incidence in Japan in 2009-2011. Jpn J Clin Oncol. 2017;47(8):762-771.
  • Tabuchi T, Murayama H, Hoshino T, Nakayama T. An Out-of-Pocket Cost Removal Intervention on Fecal Occult Blood Test Attendance. Am J Prev Med. 2017;53(2):e51-e62.
  • Nomura S, Sakamoto H, Glenn S, Tsugawa Y, Abe S, Rahman M, Brown JC, Ezoe S, Fitzmaurice C, Inokuchi T, Kassebaum N, Kawakami N, Kita Y, Kondo N, Lim S, Maruyama S, Miyata H, Mooney M, Naghavi M, Onoda T, Ota E, Otake Y, Roth G, Saito E, Tabuchi T, Takasaki Y, Tanimura T, Uechi M, Vos T, Wang H, Inoue M, Murray C, Shibuya K. Population health and regional variations of disease burden in Japan, 1990–2015: a systematic subnational analysis for the Global Burden of Disease Study 2015. Lancet. 2017;390(10101):1521-1538.
  • Tsugawa Y, Hashimoto K, Tabuchi T, Shibuya K. What can Japan learn from tobacco control in the UK? Lancet. 2017;390(10098):933-934.
  • Aida J, Matsuyama Y, Tabuchi T, Komazaki Y, Tsuboya T, Kato T, Osaka K, Fujiwara T. Trajectory of social inequalities in the treatment of dental caries among preschool children in Japan. Community Dent Oral Epidemiol. 2017;45(5):407-412.
  • Tsugawa Y, Hashimoto K, Tabuchi T, Shibuya K. Is Japan losing the fight against smoke-free legislation? BMJ Opinion. 2017.
  • Tanabe S, Hirabayashi S, Oda I, Ono H, Nashimoto A, Isobe Y, Miyashiro I, Tsujitani S, Seto Y, Fukagawa T, Nunobe S, Furukawa H, Kodera Y, Kaminishi M, Katai H. Gastric cancer treated by endoscopic submucosal dissection or endoscopic mucosal resection in Japan from 2004 through 2006: JGCA nationwide registry conducted in 2013. Gastric Cancer. 2017;20(5):834-842.
  • Aida J, Hikichi H, Matsuyama Y, Sato Y, Tsuboya T, Tabuchi T, Koyama S, Subramanian S, V, Kondo K, Osaka K, Kawachi I. Risk of mortality during and after the 2011 Great East Japan Earthquake and Tsunami among older coastal residents. Sci Rep. 2017;7(1):16591.
  • Kinoshita FL, Ito Y, Morishima T, Miyashiro I, Nakayama T. Sex differences in lung cancer survival: long-term trends using population-based cancer registry data in Osaka, Japan. Jpn J Clin Oncol. 2017;47(9):863–869.
  • Inoue H, Ito I, Niimi A, Matsumoto H, Oguma T, Tajiri T, Iwata T, Nagasaki T, Kanemitsu Y, Morishima T, Hirota T, Tamari M, Wenzel SE, Mishima M. Association of interleukin 1 receptor-like 1 gene polymorphisms with eosinophilic phenotype in Japanese adults with asthma. Respir Investig. 2017;55(6):338–347.
  • Nakagawa H, Ito H, Hosono S, Oze I, Mikami H, Hattori M, Nishino Y, Sugiyama H, Nakata K, Tanaka H. Changes in trends in colorectal cancer incidence rate by anatomic site between 1978 and 2004 in Japan. Eur J Cancer Prev. 2017;26(4):269-276.

2016

  • Ito Y, Nakaya T, Ioka A, Nakayama T, Tsukuma H, Uehara S, Kogawa Sato K, Endo G, Hayashi T. Investigation of Spatial Clustering of Biliary Tract Cancer Incidence in Osaka, Japan: Neighborhood Effect of a Printing Factory. J Epidemiol. 2016;26(9):459-463.
  • Ries L, Trama A, Nakata K, Gatta G, Botta L, Bleyer A. Cancer Incidence, Survival, and Mortality Among Adolescents and Young Adults, Cancer in Adolescents and Young Adults. Springer International Publishing. 2016 :7-41, Print ISBN 978-3-319-33677-0
  • Tabuchi T, Nakamura M, Nakayama T, Miyashiro I, Mori J, Tsukuma H. Tobacco price increase and smoking cessation in a tobacco-affordable country, Japan: a national population-based observational study. J Epidemiol. 2016;26(1):14-21.

2015

  • Tabuchi T, Ozaki K, Ioka A, Miyashiro I. Joint and independent effect of alcohol and tobacco use on the risk of subsequent cancer incidence among cancer survivors: A cohort study using cancer registries. Int J Cancer. 2015;137(9):2114-2123.
  • Tabuchi T, Hoshino T, Nakayama T. Are Partial Workplace Smoking Bans as Effective as Complete Smoking Bans? A National Population-Based Study of Smoke-Free Policy Among Japanese Employees. Nicotine Tob Res. 2015;18(5):1265-1273.
  • Uchida J, Kato K, Kukita Y, Kumagai T, Nishino K, Daga H, Nagatomo I, Inoue T, Kimura M, Oba S, Ito Y, Takeda K, Imamura F. Diagnostic Accuracy of Noninvasive Genotyping of EGFR in Lung Cancer Patients by Deep Sequencing of Plasma Cell-Free DNA. Clin Chem. 2015;61(9):1191-1196.
  • Saito J, Tabuchi T, Shibanuma A, Yasuoka J, Nakamura M, Jimba M. Only Fathers Smoking’ Contributes the Most to Socioeconomic Inequalities: Changes in Socioeconomic Inequalities in Infants’ Exposure to Second Hand Smoke over Time in Japan. PloS one. 2015;10(10): e0139512.-.
  • Nakata-Yamada K, Inoue M, Ioka A, Ito Y, Tabuchi T, Miyashiro I, Masaie H, Ishikawa J,
    Hino M, Tsukuma H. Comparison of survival of adolescents and young adults with hematologic malignancies in Osaka, Japan. Leuk Lymphoma. 2015:1-7.
  • Katanoda K, Hori M, Matsuda T, Shibata A, Nishino Y, Hattori M, Soda M, Ioka A, Sobue T, Nishimoto H. An updated report on the trends in cancer incidence and mortality in Japan, 1958-2013. Jpn J Clin Oncol. 2015;45(4):390-401.
  • Tabuchi T, Fujiwara T, Nakayama T, Miyashiro I, Tsukuma H, Ozaki K, Kondo N. Maternal and paternal indoor or outdoor smoking and the risk of asthma in their children: A nationwide prospective birth cohort study. Drug Alcohol Depend. 2015; 147:103-108.
  • Tabuchi T, Fujiwara T. Are secondhand smoke-related diseases of children associated with parental smoking cessation? Determinants of parental smoking cessation in a population-based cohort study. Prev Med. 2015; 73:81-87.
  • Chihara D, Ito H, Izutsu K, Hattori M, Nishino Y, Ioka A, Matsuda T, Ito Y. Advance and stagnation in the treatment of patients with lymphoma and myeloma: Analysis using population-based cancer registry data in Japan from 1993 to 2006. Int J Cancer. 2015;137(5):1217-1223.
  • Marubashi S, Gotoh K, Akita H, Takahashi H, Ito Y, Yano M, Ishikawa O, Sakon M. Anatomical versus non-anatomical resection for hepatocellular carcinoma. Br J Surg. 2015;102(7):776-784.

2014

  • Miyashiro I, Hiratsuka M, Sasako M, Sano T, Mizusawa J, Nakamura K, Nashimoto A, Tsuburaya A, Fukushima N. High false-negative proportion of intraoperative histological examination as a serious problem for clinical application of sentinel node biopsy for early gastric cancer: final results of the Japan Clinical Oncology Group multicenter trial JCOG0302. Gastric Cancer. 2014;17(2):316-323.
  • Kumagai K, Yamamoto N, Miyashiro I, Tomita Y, Katai H, Kushima R, Tsuda H, Kitagawa Y, Takeuchi H, Mukai M, Mano M, Mochizuki H, Kato Y, Matsuura N, Sano T. Multicenter study evaluating the clinical performance of the OSNA assay for the molecular detection of lymph node metastases in gastric cancer patients. Gastric Cancer. 2014;17(2):273-280.
  • Masuzawa T, Takiguchi S, Hirao M, Imamura H, Kimura Y, Fujita J, Miyashiro I, Tamura S, Hiratsuka M, Kobayashi K, Fujiwara Y, Mori M, Doki Y. Comparison of Perioperative and Long-term Outcomes of Total and Proximal Gastrectomy for Early Gastric Cancer: A Multi-institutional Retrospective Study. World J Surg. 2014;38(5):1100-1106.
  • Tabuchi Takahiro, Nakaya T, Fukushima W, Matsunaga I, Ohfuji S, Kondo K, Inui M, Sayanagi Y, Hirota Y, Kawano E, Fukuhara H. Individualized and institutionalized residential place-based discrimination and self-rated health: a cross-sectional study of the working-age general population in Osaka city, Japan. BMC Public Health. 2014;14(1):449-.
  • Ito Y, Nakaya T, Nakayama T, Miyashiro I, Ioka A, Tsukuma H, Rachet B. Socioeconomic inequalities in cancer survival: A population-based study of adult patients diagnosed in Osaka, Japan, during the period 1993-2004. Acta Oncol. 2014;53(10):1423-1433.
  • Ito Y, Miyashiro I, Ito H, Hosono S, Chihara D, Nakata-Yamada K, Nakayama M, Matsuzaka M, Hattori M, Sugiyama H, Oze I, Tanaka R, Nomura E, Nishino Y, Matsuda T, Ioka A, Tsukuma H, Nakayama T, the J-CANSIS research group. Long-term survival and conditional survival of cancer patients in Japan using population-based cancer registry data. Cancer Sci. 2014;105(11):1480-1486.

In Japanese

2016

  • 宮代 勲, . 胃がん. JACR Monograph.2016;Supplement 2 :18-29.

2015

  • 宮代 勲, 松浦成昭. 大腸癌の疫学―国際比較―. 日本臨牀 2015;73(4):44-50.
  • 宮代 勲, 富田裕彦,矢野雅彦,松浦成昭. OSNA(One-Step Nucleic Acid Amplification)法による胃癌リンパ節転移診断. 臨牀消化器内. 2015;30(7):245-248.
  • 濱 秀聡, 田淵貴大、伊藤ゆり、福島若葉、松永一朗、宮代勲、中山富雄. 喫煙習慣と肺および胃、大腸がん検診受診の関連. 日本公衆衛生雑誌. 2016;63(3):126-134.
  • 中田佳世, 井岡亜希子、宮代 勲、松浦成昭. AYA(adolescent and young adult)世代のがんの疫学と医療の現状、問題点について. 日本小児血液・がん学会雑誌. 2015;52(3):258-262.
  • 伊藤ゆり, 中山富雄. 肺がん生存率の国際比較. 肺癌. 2015;55(4):266-272.

2014

  • 中田佳世, 井岡亜希子、井上雅美、津熊秀明. AYA(adolescent and young adult)世代のがんの疫学と医療、特に白血病の治療方針について. 日本小児血液・がん学会雑誌. 2014;51(2):120-126.
  • 中山富雄, . 低線量CT肺がん検診の欧米の大規模評価研究の結果は日本に適合できるか. 癌と化学療法. 2014;41(8):951-954.
  • 中山富雄, . 低線量CT検診のエビデンス-NLSTのサブ解析の詳細-. 日本CT検診学会誌. 2014;21(2):91-95.
  • 井岡亜希子, 伊藤ゆり、中田佳世、津熊秀明. がんの生存率を一般向けにどのように情報提供するか. JACR Monograph. 2014;20:49-58.
  • 田淵貴大, 中村正和. 日本における年齢階級・学歴・医療保険別の受動喫煙格差. JACR Monograph. 2014;20:39-48.
  • 伊藤ゆり, 中谷友樹, 宮代勲, 井岡亜希子, 中山富雄. .大阪府におけるがん患者の生存率の社会経済格差:1993-2004年診断患者による分析. JACR Monograph. 2014;20:69-78.

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